Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function
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چکیده
منابع مشابه
Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function
Sleep is an ancient animal behavior that is regulated similarly in species ranging from flies to humans. Various genes that regulate sleep have been identified in invertebrates, but whether the functions of these genes are conserved in mammals remains poorly explored. Drosophila insomniac (inc) mutants exhibit severely shortened and fragmented sleep. Inc protein physically associates with the C...
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In a forward genetic screen in Drosophila, we have isolated insomniac, a mutant that severely reduces the duration and consolidation of sleep. Anatomically restricted genetic manipulations indicate that insomniac functions within neurons to regulate sleep. insomniac expression does not oscillate in a circadian manner, and conversely, the circadian clock is intact in insomniac mutants, suggestin...
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Yukiko Goda is a senior group leader at the Medical Research Council Cell Biology Unit and the Laboratory for Molecular Cell Biology and an honorary professor in the Department of Neuroscience, Physiology and Pharmacology at University College London, UK. Research efforts in her laboratory are directed towards mechanisms underlying structural and functional plasticity at individual and amongst ...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2017
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1006815